Index of Diseases



Definition: The cutaneous and occasional systemic reactions associated with vaccination using smallpox (variola) vaccine. Annotation: caused by a poxvirus after smallpox vaccination ID#: D014615

Vaginal Discharge

Definition: A common gynecologic disorder characterized by an abnormal, nonbloody discharge from the genital tract. Annotation: note category; nonbloody; IM; coord with cause of discharge (IM) ID#: D019522

Vaginal Diseases

Definition: Annotation: inflamm dis = VAGINITIS ID#: D014623

Vaginal Fistula

Definition: An abnormal passage communicating with the vagina. Annotation: fistula policy: Manual 23.19+; RECTOVAGINAL FISTULA & VESICOVAGINAL FISTULA are available ID#: D014624

Vaginal Neoplasms

Definition: Tumors or cancer of the VAGINA. Annotation: coord IM with histol type of neopl (IM) ID#: D014625


Definition: Inflammation of the vagina characterized by pain and a purulent discharge. Annotation: TRICHOMONAS VAGINITIS is also available ID#: D014627

Vaginosis, Bacterial

Definition: Polymicrobial, nonspecific vaginitis associated with positive cultures of Gardnerella vaginalis and other anaerobic organisms and a decrease in lactobacilli. It remains unclear whether the initial pathogenic event is caused by the growth of anaerobes or a primary decrease in lactobacilli. Annotation: coord IM with specific bacterium/infections heading (IM) or specific bacterium (IM) if no precoord bact/infect term exists; DF: VAGINOSIS BACT ID#: D016585

Vagus Nerve Diseases

Definition: Diseases of the tenth cranial nerve, including brain stem lesions involving its nuclei (solitary, ambiguus, and dorsal motor), nerve fascicles, and intracranial and extracranial course. Clinical manifestations may include dysphagia, vocal cord weakness, and alterations of parasympathetic tone in the thorax and abdomen. Annotation: neopl: coord IM with CRANIAL NERVE NEOPLASMS (IM) + histol type of neopl (IM) ID#: D020421


Definition: A varicose condition of the veins of the pampiniform plexus, forming a swelling that feels like a "bag of worms," appearing bluish through the skin of the scrotum, and accompanied by a constant pulling, dragging, or dull pain in the scrotum. (Dorland, 27th ed) Annotation: abnorm dilat of veins of the spermatic cord ID#: D014646

Varicose Ulcer

Definition: Ulcer due to varicose veins. Chronic venous insufficiency in the deep veins of the legs leads to shunting the venous return into the superficial veins, in which pressure and flow rate, as well as oxygen content, are increased. Annotation: assume to be of legs & do not coord with LEG ULCER ID#: D014647

Varicose Veins

Definition: Annotation: assume to be of legs so do not coord with LEG; other sites: coord VARICOSE VEINS (IM) + organ /blood supply (IM), not organ/dis, as orbit varix = VARICOSE VEINS (IM) + ORBIT /blood supply (IM) (not ORBITAL DISEASES) ID#: D014648

Vascular Diseases

Definition: Annotation: GEN or unspecified vasc dis but CARDIOVASCULAR DISEASES; CEREBROVASCULAR DISORDERS & PERIPHERAL VASCULAR DISEASES are also available; inflamm vasc dis = VASCULITIS; vasc compression syndrome: see note on PERIPHERAL VASCULAR DISEASES ID#: D014652

Vascular Fistula

Definition: An abnormal passage between two or more arteries, or between an artery and a vein. Annotation: GEN or unspecified; prefer ARTERIO-ARTERIAL FISTULA or ARTERIOVENOUS FISTULA; fistula policy: Manual 23.19+ ID#: D016157

Vascular Headaches

Definition: A group of disorders characterized by recurrent headaches associated with abnormal dilation and constriction of cerebral blood vessels. Representative disorders from this category include MIGRAINE; CLUSTER HEADACHE; and paroxysmal hemicrania. Annotation: GEN: prefer specifics ID#: D014653

Vascular Hemostatic Disorders

Definition: Alterations in the mechanical integrity or structure of the blood vessels leading to bleeding disorders. Annotation: ID#: D020141

Vascular Neoplasms

Definition: Neoplasms located in vascular tissue or specific veins. They are differentiated from NEOPLASMS, VASCULAR TISSUE which are neoplasms composed of vascular tissue, such as ANGIOFIBROMA or HEMANGIOMA. Annotation: neopl located in veins & arteries: do not confuse with NEOPLASMS, VASCULAR TISSUE, neopl composed of vascular tissue; /blood supply /chem /secret /second /ultrastruct permitted; coord IM with specific vessel (IM) + histol type of neopl (IM); DF: VASCULAR NEOPL ID#: D019043


Definition: Inflammation of a blood vessel. Annotation: inflamm of blood vessels only; GEN or unspecified; consider ARTERITIS or PHLEBITIS & their indentions; hemorrhagic vasculitis = PURPURA, SCHOENLEIN-HENOCH ID#: D014657

Vasculitis, Allergic Cutaneous

Definition: Vasculitis due to allergic reaction, marked by such cutaneous lesions as papules, macules, vesicles, urticarial wheals, purpura, and small ulcers, and accompanied by itching and usually a slight fever and malaise. Annotation: ID#: D014658

Vasculitis, Central Nervous System

Definition: Inflammation of blood vessels within the central nervous system. Etiologies include autoimmune disorders (see also LUPUS ERYTHEMATOSUS, SYSTEMIC; POLYARTERITIS NODOSA; WEGENER'S GRANULOMATOSIS), infections, exposure to radiation or toxins, and other conditions. Autoimmune or idiopathic vasculitides limited to the central nervous system are referred to as primary CNS vasculitides. CNS vasculitides associated with a systemic process or known pathogens are referred to as secondary CNS vasculitides. Clinical manifestations are highly variable but include headaches; SEIZURES; behavioral alterations; INTRACRANIAL HEMORRHAGES; transient ischemic attacks (ISCHEMIC ATTACK, TRANSIENT); and BRAIN INFARCTION. (From Adams et al., Principles of Neurology, 6th ed, pp856-61) Annotation: DF: note short X refs ID#: D020293

Vasculitis, Hypersensitivity

Definition: Heterogeneous group of disorders characterized by a vasculitic syndrome presumed to be associated with a hypersensitivity reaction following exposure to an antigen such as an infectious agent, a drug, or other foreign or endogenous substance (Wilson et al, Harrison's Principles of Internal Medicine, 12th ed, p1459). Annotation: ID#: D018366

Vasospasm, Intracranial

Definition: Narrowing of the lumen of one or more intracranial arteries due to contraction of arterial smooth muscle or to morphologic changes of the blood vessel wall. Large blood vessels near the base of the brain are primarily affected and reduced blood flow may result in hypoxic-ischemic brain injury (HYPOXIA-ISCHEMIA, BRAIN). Vasospasm may be associated with SUBARACHNOID HEMORRHAGE; CRANIOCEREBRAL TRAUMA; and other disorders. (From Neurosurg Clin N Am, 1998 Jul;9(3):615-27) Annotation: ID#: D020301

Velopharyngeal Insufficiency

Definition: Failure of the soft palate to reach the posterior pharyngeal wall. It may be caused by cleft palate surgery, palatal or pharyngeal abnormalities or injury, or neuromuscular dysfunction of the velopharyngeal sphincter. It causes hypernasality of speech. Annotation: failure of soft palate to reach posterior wall of pharynx ID#: D014681

Venereal Tumors, Veterinary

Definition: Tumors most commonly seen on or near the genitalia. They are venereal, most likely transmitted through transplantation of cells by contact. Metastases have been reported. Spontaneous regression may occur. Annotation: do not coord with GENITALIA or specific genital term unless especially discussed; coord IM with precoord animal/dis term (IM) + animal (NIM); /blood supply /chem /second /secret /ultrastruct permitted; don't forget check tag ANIMAL ID#: D014685

Venous Insufficiency

Definition: Inadequacy of the venous valves and impairment of venous return (venous stasis) usually from the legs, often with edema and sometimes with stasis ulcers at the ankle. Annotation: GEN or unspecified but usually of the legs; coord IM with specific vein (IM) or organ /blood supply (IM) if pertinent ID#: D014689

Venous Thrombosis

Definition: The formation or presence of a thrombus within a vein. Annotation: GEN: prefer specifics; coord IM with specific vein (IM) if precoord is not available ID#: D020246

Ventricular Dysfunction

Definition: A condition in which the ventricles of the heart exhibit a decreased functionality. Annotation: ventric refers to the heart, not the cerebral ventricles; GEN or unspecified: prefer VENTRICULAR DYSFUNCTION, LEFT or VENTRICULAR DYSFUNCTION, RIGHT ID#: D018754

Ventricular Dysfunction, Left

Definition: A condition in which the left ventricle of the heart exhibits a decreased functionality. This decreased function could lead to congestive heart failure or myocardial infarction, among other cardiovascular diseases. Diagnostic measurements that indicate this condition include a diminished ejection fraction and a depressed level of motility of the left ventricular wall. Annotation: ventric refers to the heart, not the cerebral ventricles ID#: D018487

Ventricular Dysfunction, Right

Definition: A condition in which the right ventricle of the heart exhibits a decreased functionality. This decreased function could lead to congestive heart failure or myocardial infarction, among other cardiovascular diseases. Diagnostic measurements that indicate this condition include a diminished ejection fraction and a depressed level of motility of the right ventricular wall. Annotation: ventric refers to the heart, not the cerebral ventricles ID#: D018497

Ventricular Fibrillation

Definition: Annotation: does not include ventric flutter ( = ARRHYTHMIA (IM) + HEART VENTRICLE (NIM)) ID#: D014693

Ventricular Outflow Obstruction

Definition: Occlusion of the ventricular outflow or inflow tract on either side of the heart. It may result from a congenital defect or predisposing heart disease, or as a complication of surgery or tumors of the heart or its vessels. Annotation: ID#: D014694

Ventricular Premature Complexes

Definition: Premature contractions of the ventricle, the most common of all arrhythmias. In the absence of heart disease, they are not of great clinical significance, but in patients with coronary disease, they represent a constant danger of ventricular tachycardia or fibrillation and sudden death. The longer-term prognosis for asymptomatic, healthy subjects with frequent and complex ectopy is similar to that for the healthy United States population. (From Sokolow, et al., Clinical Cardiology, 5th ed, p491) Annotation: a type of arrhythmia ID#: D018879

Ventricular Septal Rupture

Definition: Rupture of the intraventricular septum of the heart, usually secondary to myocardial infarction. Annotation: ID#: D018658

Vertebral Artery Dissection

Definition: Dissection of the wall of the vertebral artery, leading to the formation of an aneurysm that may occlude the vessel. Thrombus formation may occur and give rise to emboli. Cervical fractures or related NECK INJURIES and CRANIOCEREBRAL TRAUMA are commonly associated conditions, although this process may occur spontaneously. Ischemia, infarction, and hemorrhage in the vascular distribution of the affected vertebral artery may complicate this condition. Annotation: ID#: D020217

Vertebrobasilar Insufficiency

Definition: Localized or diffuse reduction in blood flow through the vertebrobasilar arterial system, which supplies the BRAIN STEM; CEREBELLUM; OCCIPITAL LOBE; medial TEMPORAL LOBE; and THALAMUS. Characteristic clinical features include SYNCOPE; lightheadedness; visual disturbances; and VERTIGO. BRAIN STEM INFARCTIONS or other BRAIN INFARCTION may be associated. Annotation: BRACHIAL-BASILAR INSUFFICIENCY SYNDROME see SUBCLAVIAN STEAL SYNDROME is available ID#: D014715


Definition: An illusion of movement, either of the external world revolving around the individual or of the individual revolving in space. Vertigo may be associated with disorders of the inner ear, vestibular nerve, brainstem, and cerebral cortex. Lesions in the temporal and parietal lobes may be associated with FOCAL SEIZURES that may feature vertigo as an ictal manifestation. (From Adams et al., Principles of Neurology, 6th ed, pp300-1) Annotation: differentiate from DIZZINESS, "sensation of unsteadiness or lightheadedness", but use word of text ID#: D014717

Vesico-Ureteral Reflux

Definition: The passage of urine from the bladder back into a ureter. (Dorland, 27th ed) Annotation: reflux of urine from bladder back into a ureter ID#: D014718

Vesicovaginal Fistula

Definition: An abnormal communication between the bladder and the vagina. Annotation: fistula policy: Manual 23.19+ ID#: D014719

Vesicular Exanthema of Swine

Definition: A calicivirus infection of swine characterized by hydropic degeneration of the oral and cutaneous epithelia. Annotation: caused by a calicivirus; don't forget also SWINE (NIM) & check tag ANIMAL ID#: D014720

Vestibular Diseases

Definition: Diseases of the vestibule, the part of the inner ear that contains organs involved with balance. Annotation: inner ear dis ID#: D015837

Vestibular Neuronitis

Definition: Idiopathic inflammation of the vestibular nerve, characterized clinically by the acute or subacute onset of vertigo, nausea, and imbalance. The cochlear nerve is typically spared and hearing loss and tinnitus do not usually occur. Symptoms usually resolve over a period of days to weeks. (Adams et al., Principles of Neurology, 6th ed, p304) Annotation: ID#: D020338

Vestibulocochlear Nerve Diseases

Definition: Diseases of the vestibular and/or cochlear (acoustic) nerves, which join to form the vestibulocochlear nerve. VESTIBULAR NEURITIS, cochlear neuritis, and acoustic neuromas (NEUROMA, ACOUSTIC) are relatively common conditions that affect these nerves. Clinical manifestations vary with which nerve is primarily affected, and include hearing loss, vertigo, and tinnitus. Annotation: coord IM with COCHLEAR NERVE (IM) for cochlear nerve dis or with VESTIBULAR NERVE (IM) for vestibular nerve dis: neopl: coord IM with CRANIAL NERVE NEOPLASMS (IM) + histol type of neopl (IM); DF: ACOUSTIC NERVE DIS ID#: D000160

Vibrio Infections

Definition: Infections with bacteria of the genus VIBRIO. Annotation: gram-neg bact infect; V. comma infection = CHOLERA ID#: D014735


Definition: An endocrine tumor, usually arising in the pancreas, that produces vasoactive intestinal polypeptide, which is the mediator of a syndrome of watery diarrhea, hypokalemia, and hypochlorhydria, leading to renal failure and death. (Dorland, 27th ed) Annotation: /blood supply /chem /second /secret /ultrastruct permitted; coord IM with PANCREATIC NEOPLASMS (IM); this is a tumor of the pancreatic delta cells ID#: D003969


Definition: The presence of viruses in the blood. Annotation: coord with specific virus disease or specific virus if specific virus dis is not in MeSH (do not use /blood to indicate -emia) ID#: D014766


Definition: Development of masculine traits in the female. Annotation: check the tag FEMALE ID#: D014770

Virus Diseases

Definition: A general term for diseases produced by viruses. Annotation: GEN: prefer specifics; /drug ther: consider also ANTIVIRAL AGENTS ID#: D014777


Definition: The prolapse or downward displacement of the viscera. Annotation: "prolapse or downward displacement of the viscera" ID#: D014782

Vision Disorders

Definition: Visual impairments limiting one or more of the basic functions of the eye: visual acuity, dark adaptation, color vision, or peripheral vision. These may result from EYE DISEASES; OPTIC NERVE DISEASES; VISUAL PATHWAY diseases; OCCIPITAL LOBE diseases; OCULAR MOTILITY DISORDERS; and other conditions. Visual disability refers to inability of the individual to perform specific visual tasks, such as reading, writing, orientation, or traveling unaided. (From Newell, Ophthalmology: Principles and Concepts, 7th ed, p132) Annotation: disord of vision, not dis of the eye ( = EYE DISEASES); GEN or unspecified: prefer specifics; /diag: consider also DIAGNOSTIC TECHNIQUES, OPHTHALMOLOGICAL ID#: D014786

Vision, Low

Definition: Vision considered to be inferior to normal vision as represented by accepted standards of acuity, field of vision, or motility. Low vision generally refers to visual disorders that are caused by diseases that cannot be corrected by refraction (e.g., MACULAR DEGENERATION; RETINITIS PIGMENTOSA; DIABETIC RETINOPATHY, etc.). Annotation: do not make a diagnosis: use term of author ID#: D015354


Definition: Demyelinating leukoencephalomyelitis of sheep caused by the VISNA-MAEDI VIRUS. It is similiar to but not the same as SCRAPIE. Annotation: caused by a lentivirus; don't forget also SHEEP (NIM) & check tag ANIMAL ID#: D016182

Vitamin A Deficiency

Definition: A nutritional condition produced by a deficiency of VITAMIN A in the diet, characterized by NIGHT BLINDNESS and other ocular manifestations such as dryness of the conjunctiva and later of the cornea (XEROPHTHALMIA). Vitamin A deficiency is a very common problem worldwide, particularly in developing countries as a consequence of famine or shortages of vitamin A-rich foods. In the United States it is found among the urban poor, the elderly, alcoholics, and patients with malabsorption. (From Cecil Textbook of Medicine, 19th ed, p1179) Annotation: DF: VITAMIN A DEFIC ID#: D014802

Vitamin B 12 Deficiency

Definition: A nutritional condition produced by a deficiency of VITAMIN B 12 in the diet, characterized by megaloblastic anemia. Since vitamin B 12 is not present in plants, humans have obtained their supply from animal products, from multivitamin supplements in the form of pills, and as additives to food preparations. A wide variety of neuropsychiatric abnormalities is also seen in vitamin B 12 deficiency and appears to be due to an undefined defect involving myelin synthesis. (From Cecil Textbook of Medicine, 19th ed, p848) Annotation: coord IM with specific B 12 vitamin /defic (IM); DF: VITAMIN B 12 DEFIC ID#: D014806

Vitamin B 6 Deficiency

Definition: A nutritional condition produced by a deficiency of VITAMIN B 6 in the diet, characterized by dermatitis, glossitis, cheilosis, and stomatitis. Marked deficiency causes irritability, weakness, depression, dizziness, peripheral neuropathy, and seizures. In infants and children typical manifestations are diarrhea, anemia, and seizures. Deficiency can be caused by certain medications, such as isoniazid. Annotation: ID#: D026681

Vitamin B Deficiency

Definition: Annotation: ID#: D014804

Vitamin D Deficiency

Definition: A nutritional condition produced by a deficiency of VITAMIN D in the diet, insufficient production of vitamin D in the skin, inadequate absorption of vitamin D from the diet, or abnormal conversion of vitamin D to its bioactive metabolites. It is manifested clinically as RICKETS in children and OSTEOMALACIA in adults. (From Cecil Textbook of Medicine, 19th ed, p1406) Annotation: DF: VITAMIN D DEFIC ID#: D014808

Vitamin E Deficiency

Definition: A nutritional condition produced by a deficiency of VITAMIN E in the diet, characterized by posterior column and spinocerebellar tract abnormalities, areflexia, ophthalmoplegia, and disturbances of gait, proprioception, and vibration. In premature infants vitamin E deficiency is associated with hemolytic anemia, thrombocytosis, edema, intraventricular hemorrhage, and increasing risk of retrolental fibroplasia and bronchopulmonary dysplasia. An apparent inborn error of vitamin E metabolism, named familial isolated vitamin E deficiency, has recently been identified. (Cecil Textbook of Medicine, 19th ed, p1181) Annotation: DF: VITAMIN E DEFIC ID#: D014811

Vitamin K Deficiency

Definition: A nutritional condition produced by a deficiency of VITAMIN K in the diet, characterized by an increased tendency to hemorrhage (HEMORRHAGIC DISORDERS). Such bleeding episodes may be particularly severe in newborn infants. (From Cecil Textbook of Medicine, 19th ed, p1182) Annotation: DF: VITAMIN K DEFIC ID#: D014813


Definition: A disorder consisting of areas of macular depigmentation, commonly on extensor aspects of extremities, on the face or neck, and in skin folds. Age of onset is often in young adulthood and the condition tends to progress gradually with lesions enlarging and extending until a quiescent state is reached. Annotation: macular depigmentation ID#: D014820

Vitreoretinopathy, Proliferative

Definition: Vitreoretinal membrane shrinkage or contraction secondary to the proliferation of primarily retinal pigment epithelial cells and glial cells, particularly fibrous astrocytes, followed by membrane formation. The formation of fibrillar collagen and cellular proliferation appear to be the basis for the contractile properties of the epiretinal and vitreous membranes. Annotation: shrinkage of vitreoretinal membrane after prolif of retinal pigment cells ID#: D018630

Vitreous Detachment

Definition: Detachment of the corpus vitreum (VITREOUS BODY) from its normal attachments, especially the retina, due to shrinkage from degenerative or inflammatory conditions, trauma, myopia, or senility. Annotation: ID#: D020255

Vitreous Hemorrhage

Definition: Hemorrhage into the VITREOUS BODY. Annotation: ID#: D014823

Vocal Cord Paralysis

Definition: Paralysis of one or both vocal cords, which produces hoarseness or aphonia. This condition may be caused by diseases of the medulla (e.g., LATERAL MEDULLARY SYNDROME), VAGUS NERVE, or recurrent laryngeal nerve. Neuromuscular junction diseases and local myopathic processes may also affect vocal cord function. (Adams et al., Principles of Neurology, 6th ed, p1380) Annotation: coord with RECURRENT LARYNGEAL NERVE if pertinent ID#: D014826

Voice Disorders

Definition: Disorders of voice pitch, loudness, or quality. Dysphonia refers to impaired utterance of sounds by the vocal folds. Annotation: available also is HOARSENESS ID#: D014832


Definition: The forcible expulsion of the contents of the stomach through the mouth. Annotation: /chem ind: consider also EMETICS; /drug ther: consider also ANTIEMETICS; Jamaican vomiting sickness: index PLANT POISONING + HYPOGLYCINS /pois ID#: D014839

Vomiting, Anticipatory

Definition: Vomiting caused by expectation of discomfort or unpleasantness. Annotation: do not use /chem ind in cancer chemother: prefer /etiol, /psychol, etc. ID#: D014840

von Willebrand Disease

Definition: Group of hemorrhagic disorders in which the von Willebrand factor (Factor VIII-related antigen) is either quantitatively or qualitatively abnormal. They are usually inherited as an autosomal dominant trait though rare kindreds are autosomal recessive. Symptoms vary depending on severity and disease type but may include prolonged bleeding time, deficiency of factor VIII, and impaired platelet adhesion. Annotation: do not coord with INFANT, NEWBORN, DISEASES ID#: D014842

Vulvar Diseases

Definition: Diseases of the vulva. Annotation: inflamm dis = VULVITIS ID#: D014845

Vulvar Neoplasms

Definition: Tumors or cancer of the VULVA. Annotation: /blood supply /chem /second /secret /ultrastruct permitted; coord IM with histol type of neopl (IM) ID#: D014846


Definition: Inflammation of the vulva. (Dorland, 27th ed) Annotation: inflamm of vulva ID#: D014847


Definition: Inflammation of the vulva and vagina or vulvovaginal glands. (Dorland, 27th ed) Annotation: inflamm of vulva & vagina ID#: D014848